A cautionary note: the actions of adenosine agonists and antagonists may be reversed under certain conditions in primary cultures.

@article{Brooke2000ACN,
  title={A cautionary note: the actions of adenosine agonists and antagonists may be reversed under certain conditions in primary cultures.},
  author={Sheila M. Brooke and Robert Morris Sapolsky},
  journal={Brain research bulletin},
  year={2000},
  volume={51 4},
  pages={307-12}
}
It is now generally accepted that adenosine has a neuroprotective role in the central nervous system. Agonists of adenosine such as 2-chloroadenosine (2-ClA) have been shown to be neuroprotective, while antagonists such as 8-phenyltheophylline (8-PT) increase neurotoxicity. However, paradoxical results have been reported with adenosine analogues, especially with respect to length of time of administration. We observe similarly contradictory findings with respect to 2-ClA and 8-PT actions in… CONTINUE READING

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