A caudorostral wave of RALDH2 conveys anteroposterior information to the cardiac field.

@article{Hochgreb2003ACW,
  title={A caudorostral wave of RALDH2 conveys anteroposterior information to the cardiac field.},
  author={Tatiana Hochgreb and Vania L F Linhares and Diego C Menezes and Allysson C Sampaio and Chao Yun Irene Yan and Wellington V Cardoso and Nadia Rosenthal and Jos{\'e} Xavier-Neto},
  journal={Development},
  year={2003},
  volume={130 22},
  pages={5363-74}
}
Establishment of anteroposterior (AP) polarity is one of the earliest decisions in cardiogenesis and plays an important role in the coupling between heart and blood vessels. Recent research implicated retinoic acid (RA) in the communication of AP polarity to the heart. We utilized embryo culture, in situ hybridization, morphometry, fate mapping and treatment with the RA pan-antagonist BMS493 to investigate the relationship between cardiac precursors and RA signalling. We describe two phases of… CONTINUE READING
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