A catechol-O-methyltransferase that is essential for auditory function in mice and humans.

Abstract

We have identified a previously unannotated catechol-O-methyltranferase (COMT), here designated COMT2, through positional cloning of a chemically induced mutation responsible for a neurobehavioral phenotype. Mice homozygous for a missense mutation in Comt2 show vestibular impairment, profound sensorineuronal deafness, and progressive degeneration of the… (More)
DOI: 10.1073/pnas.0807219105

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