A catalytic subunit of cyclic AMP-dependent protein kinase, PKAC-1, regulates asexual differentiation in Neurospora crassa.

@article{Banno2005ACS,
  title={A catalytic subunit of cyclic AMP-dependent protein kinase, PKAC-1, regulates asexual differentiation in Neurospora crassa.},
  author={Shinpei Banno and Noriyuki Ochiai and Rieko Noguchi and Makoto Kimura and Isamu Yamaguchi and Sei-ichi Kanzaki and Tadako Murayama and Makoto Fujimura},
  journal={Genes & genetic systems},
  year={2005},
  volume={80 1},
  pages={25-34}
}
A cyclic AMP (cAMP)-dependent protein kinase pathway has been shown to regulate growth, morphogenesis and virulence in filamentous fungi. However, the precise mechanisms of regulation through the pathway remain poorly understood. In Neurospora crassa, the cr-1 adenylate cyclase mutant exhibits colonial growth with short aerial hyphae bearing conidia, and the mcb mutant, a mutant of the regulatory subunit of cAMP-dependent protein kinase (PKA), shows the loss of growth polarity at the… CONTINUE READING

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