A catalytic-independent role for the LUBAC in NF-κB activation upon antigen receptor engagement and in lymphoma cells.

@article{Dubois2014ACR,
  title={A catalytic-independent role for the LUBAC in NF-κB activation upon antigen receptor engagement and in lymphoma cells.},
  author={Sonia M Dubois and Catherine Alexia and Youtong Wu and H{\'e}lo{\"i}se M. Leclair and Claire Leveau and Emilie Schol and Thierry Fest and Karin Tarte and Zhijian J Chen and Julie Gavard and Nicolas Bid{\`e}re},
  journal={Blood},
  year={2014},
  volume={123 14},
  pages={2199-203}
}
Antigen receptor-mediated nuclear factor κB (NF-κB) activation relies on the formation of a large multi-protein complex that contains CARMA1, BCL10, and MALT1 (CBM complex). This signalosome is pirated in the activated B-cell-like subgroup of diffuse large B-cell lymphoma (ABC DLBCL) to drive aberrant NF-κB activation, thereby promoting cell survival and propagation. Using an unbiased proteomic approach, we screened for additional components of the CBM in lymphocytes. We found that the linear… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 26 references

Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma.

Proceedings of the National Academy of Sciences of the United States of America • 2009
View 1 Excerpt
Highly Influenced

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains.

Proceedings of the National Academy of Sciences of the United States of America • 2013
View 1 Excerpt

Similar Papers

Loading similar papers…