A catalytic enantioselective approach to tetrol bearing vicinal all-carbon quaternary stereogenic centers.

@article{Yang2017ACE,
  title={A catalytic enantioselective approach to tetrol bearing vicinal all-carbon quaternary stereogenic centers.},
  author={Hui Yang and Kou-Sen Cao and Wen-Hua Zheng},
  journal={Chemical communications},
  year={2017},
  volume={53 26},
  pages={3737-3740}
}
The first highly enantioselective catalytic protocol for selective manipulation of tetrol benzylidene acetals through chiral phosphoric acid mediated oxidative desymmetrization is reported. This efficient approach provides a general access to vicinal all-carbon quaternary stereogenic center structural motifs, as well as structures containing vicinal tertiary and quaternary stereocenters enantioselectively. The synthetic utility has been furthermore demonstrated by transformations and gram-scale… CONTINUE READING