A catalytic domain exosite (Cys527-Cys542) in factor XIa mediates binding to a site on activated platelets.

@article{Miller2007ACD,
  title={A catalytic domain exosite (Cys527-Cys542) in factor XIa mediates binding to a site on activated platelets.},
  author={Tara Nikole Miller and Dipali Sinha and Tim Baird and Peter N. Walsh},
  journal={Biochemistry},
  year={2007},
  volume={46 50},
  pages={14450-60}
}
The zymogen, factor XI, and the enzyme, factor XIa, interact specifically with functional receptors on the surface of activated platelets. These studies were initiated to identify the molecular subdomain within factor XIa that binds to activated platelets. Both factor XIa (Ki approximately 1.4 nM) and a chimeric factor XIa containing the Apple 3 domain of prekallikrein (Ki approximately 2.7 nM) competed with [125I]factor XIa for binding sites on activated platelets, suggesting that the factor… CONTINUE READING

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