A catalase-peroxidase for oxidation of β-lactams to their (R)-sulfoxides.

@article{Sangar2012ACF,
  title={A catalase-peroxidase for oxidation of β-lactams to their (R)-sulfoxides.},
  author={Shefali Sangar and Mohan Pal and Lomary S Moon and Ravinder Sing Jolly},
  journal={Bioresource technology},
  year={2012},
  volume={115},
  pages={102-10}
}
In this communication we report for the first time a biocatalytic method for stereoselective oxidation of β-lactams, represented by penicillin-G, penicillin-V and cephalosporin-G to their (R)-sulfoxides. The method involves use of a bacterium, identified as Bacillus pumilis as biocatalyst. The enzyme responsible for oxidase activity has been purified and characterized as catalase-peroxidase (KatG). KatG of B. pumilis is a heme containing protein showing characteristic heme spectra with soret… CONTINUE READING

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