A cassette for high-level expression in the mouse salivary glands.

@article{Laursen1997ACF,
  title={A cassette for high-level expression in the mouse salivary glands.},
  author={Jesper Laursen and J. P. Hjorth},
  journal={Gene},
  year={1997},
  volume={198 1-2},
  pages={367-72}
}
Expression in the mouse salivary glands may be used as a model system for studies involving oral cavity delivery of gene products. Previously, sequences from the mouse Psp gene were used to build a minigene construct denoted 'Lama'. This construct was used as a cassette for expression of human factor VIII light chain in mouse saliva. However, whereas the endogenous Psp mRNA is the most abundant protein-coding transcript in the parotid glands, the Lama mRNA was expressed below 1% of the level of… CONTINUE READING

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