A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis.

@article{Seol1999ACV,
  title={A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis.},
  author={Dai-wu Seol and Timothy R Billiar},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 4},
  pages={2072-6}
}
It is likely that endogenous inhibitors of the apical caspases such as caspase-9 exist to prevent undesirable activation of caspase cascades. A naturally occurring variant of caspase-9 named caspase-9S was cloned from human liver. Caspase-9S is missing most of the large subunit of caspase-9, including the catalytic site, but has the intact prodomain and small subunit. Caspase-9S did not show apoptotic activity in transfection analysis. Overexpression of caspase-9S inhibited apoptosis induced by… CONTINUE READING

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