A case study: refractory recurrent autoimmune hepatitis following liver transplantation in two male patients.

Abstract

Autoimmune hepatitis (AIH) recurs after liver transplantation and significantly impacts graft function and patient survival. In this case report, we present 2 cases of male patients with refractory recurrent AIH after liver transplantation. Each patient lost their first graft due to refractory continuous AIH. We have not noticed a similar refractory course for our female patients with AIH post-transplantation at our center. Based on our single-center experience there appears to be a gender disparity in the aggressive nature of AIH recurrence after transplantation. Despite the aggressive nature of recurrent AIH in both patients, graft loss occurred beyond 3 years for both patients and did not influence the 1- and 3-year patient survival. If these findings are validated, they may have significant impact on post-transplantation immunosuppression management in male patients.

DOI: 10.1016/j.transproceed.2013.09.028

Cite this paper

@article{Tencate2014ACS, title={A case study: refractory recurrent autoimmune hepatitis following liver transplantation in two male patients.}, author={V Tencate and Richard A. Komorowski and Drew Cronin and Joon Bae Hong and Samer Gawrieh}, journal={Transplantation proceedings}, year={2014}, volume={46 1}, pages={298-300} }