A case study of “disorganized development” and its possible relevance to genetic determinants of aging

@article{Walker2009ACS,
  title={A case study of “disorganized development” and its possible relevance to genetic determinants of aging},
  author={Richard F Walker and Lawrence C. Pakula and Maxine J. Sutcliffe and Patricia A Kruk and Jesper Graakjaer and Jerry W. Shay},
  journal={Mechanisms of Ageing and Development},
  year={2009},
  volume={130},
  pages={350-356}
}
In 1932, Bidder postulated that senescence results from "continued action of a (genetic) regulator (of development) after growth ceases (maturation occurs)." A 16-year-old girl who physically appears to be an infant has not been diagnosed with any known genetic syndrome or chromosomal abnormality. The subject's anthropometric measurements are that of an 11-month-old. Coordinated development of structures for swallowing/breathing has not occurred resulting in dysfunctional digestive and… Expand
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