A case study in biomimetic total synthesis: polyolefin carbocyclizations to terpenes and steroids.

  title={A case study in biomimetic total synthesis: polyolefin carbocyclizations to terpenes and steroids.},
  author={Ryan A. Yoder and J. N. Johnston},
  journal={Chemical reviews},
  volume={105 12},
I would like to give a warning, from a theoretical point of view, about all the carbonium ion mechanisms. They are all probably concerted reactions with a beginning and an end, and the reason you write down your carbonium mechanisms in the way you do is chiefly because in writing down on paper you are bound to write something first and then something else afterwards, and the human mind is not quick and clever as the enzyme. 
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A fifty-year love affair with organic chemistry
An autobiography by the chemist best known for total steroid synthesis and biogenetic-like cyclizations.
Classics in total synthesis
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For a review of epoxy-ene and epoxy-arene cyclizations, see: Taylor SK
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The concept of 'catalysis by minimal peptides' addresses this concept directly: Miller SJ
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Nobel Lectures, Chemistry 1922-1941
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Advanced organic chemistry
For an account of some of this work in English, see (c)
  • CIBA Foundation Symposium on Biosynthesis of Terpenes and Steroids
  • 1957
Note: translation of original text provided by Professor Eschenmoser (ETH)
  • Helv. Chim. Acta
  • 1954
Soc 1940:720. (b) Stork G, Conroy H
  • J. Am. Chem. Soc
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