A case study and a computational simulation of the European Union draft technical guidance documents for chemical safety assessment of mixtures: limitations and a tentative alternative.


Two different methods, Key Critical Component (KCC) and Composite Reciprocal (CR), are used to derive Predicted No Effect Concentration (PNECs) and Derived No Effect Level (DNELs) that are employed in mixture risk assessment. A case study was conducted on coating products and a computational simulation of the KCC and CR methods. The KCC method considers… (More)
DOI: 10.1080/15459624.2012.761022