A case study addressing the reliability of polychlorinated biphenyl levels measured at the time of breast cancer diagnosis in representing early-life exposure.

@article{Verner2011ACS,
  title={A case study addressing the reliability of polychlorinated biphenyl levels measured at the time of breast cancer diagnosis in representing early-life exposure.},
  author={M. Verner and Delphine Bachelet and Robin McDougall and Michel Charbonneau and Pascal Gu{\'e}nel and Sami M Haddad},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2011},
  volume={20 2},
  pages={
          281-6
        }
}
BACKGROUND To date, breast cancer epidemiologic studies have relied on blood or tissue specimens sampled at the time of diagnosis or a few years prior to assess lifetime exposure to polychlorinated biphenyls (PCB). In this study, we evaluated whether such PCB measurements are indicative of early-life levels by reconstructing lifetime toxicokinetic profiles for women included in the CECILE case-control study, using a physiologically based pharmacokinetic (PBPK) model. METHODS We simulated… CONTINUE READING

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Biomonitoring and Nonpersistent Chemicals—Understanding and Addressing Variability and Exposure Misclassification

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