A case report on the anxiolytic properties of nitrous oxide during labor.

  title={A case report on the anxiolytic properties of nitrous oxide during labor.},
  author={Michelle R. Collins},
  journal={Journal of obstetric, gynecologic, and neonatal nursing : JOGNN},
  volume={44 1},
  • M. Collins
  • Published 2015
  • Psychology
  • Journal of obstetric, gynecologic, and neonatal nursing : JOGNN
Widely used in Europe as a labor analgesic, nitrous oxide (N2O) is making a dramatic return in the United States. Valued for its analgesic properties, N2O also has anxiolytic characteristics. Fear and anxiety in childbirth have been associated with various negative effects, and N2O may have the potential to lessen these effects for some women. Women in the United States should have the option of using N2O during labor. 
Nitrous oxide for labor analgesia
Nitrous oxide provides a noninvasive option for laboring women and its efficacy and safety as an analgesic compared with epidural and IV pain medications are outlined.
Nitrous Oxide: Expanding Women's Options for Pain Management
Colorless, tasteless, non-irritating, slightly sweet odor Nonflammable Most rapid onset of all the inhalation agents Weak anesthetic at high doses Anxiolytic and moderate analgesic at low doses
Recreational nitrous oxide use: Prevalence and risks.
Initiating Intrapartum Nitrous Oxide in an Academic Hospital: Considerations and Challenges Symbol
The challenges that occurred during the process of initiating nitrous oxide for pain management during childbirth at an academic medical center are described and various committee roles are discussed.
Non-Neuraxial Labor Analgesia: Options
In addition to nonpharmacologic alternatives, inhaled nitrous oxide and systemic opioids represent two broad classes of non-neuraxial pharmacologic labor analgesia most commonly available and are summarized in this review.
A Nurse-Directed Model for Nitrous Oxide Use During Labor
This quality improvement project involved development and implementation of a nurse-driven, self-administered, demand-flow nitrous oxide program as an option for pain relief for laboring women in a rural community hospital.
Equimolar mixture of nitroux oxyde and oxygen during post‐operative physiotherapy in patients with cerebral palsy: A randomized, double‐blind, placebo‐controlled study
This study investigated whether the use of N2O improves the efficacy of post‐operative physiotherapy after multilevel surgery in patients with cerebral palsy.
Beyond the epidural: Alternatives to neuraxial labor analgesia.
The effectiveness of foot reflexology in reducing anxiety and duration of labor in primiparas: An open-label randomized controlled trial.


Nitrous oxide for labor analgesia: expanding analgesic options for women in the United States.
The use of N2O for pain management during labor, including its history, properties, clinical indications, and use and environmental safety issues, is discussed.
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Highlights of nursing care for women using self-administered nitrous oxide during labor and birth are presented.
Nitrous oxide for relief of labor pain: a systematic review.
  • M. Rosen
  • Medicine
    American journal of obstetrics and gynecology
  • 2002
The perioperative use of nitrous oxide: renaissance of an old gas or funeral of an ancient relict?
When avoided in patients at risk for adverse events, N2O is still a valuable supplement to general anesthesia and a potent procedural analgesic drug, and in the latter, its use by nonanesthesiologists should be discouraged.
Biologic Effects of Nitrous Oxide: A Mechanistic and Toxicologic Review
Although it would seem prudent to avoid nitrous oxide in certain vulnerable populations, current evidence in support of a more widespread proscription from clinical practice is unconvincing.
Nitrous Oxide in Early Labor Safety and Analgesic Efficacy Assessed by a Double‐blind, Placebo‐controlled Study
While intermittent self-administered 50% nitrous oxide in oxygen does not appear to predispose parturient women to hemoglobin oxygen desaturation, its analgesic effect has yet to be clearly demonstrated.
Hormonal responses to analgesic nitrous oxide in man.
The increase in prolactin and decrease in cortisol levels are similar to the hormonal changes associated with administration of opioids in man and the findings of other workers that cortisol levels may not always be correlated with ACTH levels are confirmed.
Nitrous oxide inhalation is a safe and effective way to facilitate procedures in paediatric outpatient departments
The pretreatment with nitrous oxide is a time effective and safe method for use at paediatric outpatient departments to reduce pain, facilitate venous cannulation, and thereby reduce the number of costly cancellations of planned procedures.
The Management of Breakthrough Pain During Labour
This article proposes an aggressive response to epidural breakthrough pain using appropriate drug supplementation and, if necessary, the placement of a new epidural catheter.