A case of slowly progressive type 1 diabetes with unstable glycemic control caused by unusual insulin antibody and successfully treated with steroid therapy.

@article{Matsuyoshi2006ACO,
  title={A case of slowly progressive type 1 diabetes with unstable glycemic control caused by unusual insulin antibody and successfully treated with steroid therapy.},
  author={Akiko Matsuyoshi and Seiya Shimoda and Kaku Tsuruzoe and Kayo Taketa and Takeshi Chirioka and Fumi Sakamoto and Michiharu Sakakida and Nobuhiro Miyamura and Eiichi Araki},
  journal={Diabetes research and clinical practice},
  year={2006},
  volume={72 3},
  pages={238-43}
}
A 75-year-old man with type 1 diabetes and history of insulin therapy for previous 3 years using only human recombinant ones was suffering from unstable glycemic control. He had a high level of total insulin and a high titer of insulin antibodies (IA) (bound/total ratio: 89.8%). Low affinity constant (k(1): 0.0312 x 10(8) M(-1)) and high binding capacity (b(1): 51.8 x 10(-8) M) of IA in the patient detected by the Scatchard analysis were not compatible with those of IA associated with exogenous… CONTINUE READING