A case of severe 1,25-dihydroxyvitamin D-mediated hypercalcemia due to a granulomatous disorder.

@article{Zhang2012ACO,
  title={A case of severe 1,25-dihydroxyvitamin D-mediated hypercalcemia due to a granulomatous disorder.},
  author={Jane Tong Wen Zhang and Charles Chan and Sun Young Kwun and Katherine Ann Benson},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2012},
  volume={97 8},
  pages={2579-83}
}
BACKGROUND Profound hypercalcemia is usually due to underlying malignancy. CASE We describe a case of granulomatous myositis presenting with extreme hypercalcemia of 20.1 mg/dl and generalized weakness that did not resolve despite rapid correction of serum calcium. The disease process was unmasked by cholecalciferol supplementation. Initial search for a malignant process yielded no diagnosis, but an elevated 1,25-dihydroxyvitamin D level, in the setting of a suppressed PTH and undetectable… CONTINUE READING