A case of low-dose oral methotrexate-induced reversible neurotoxicity.

Abstract

Reversible Neurotoxicity Methotrexate (MTX) has poor central nervous system penetration as an oral agent. Although commonly seen with intrathecal dosing, there are only few reports of oral MTX induced cerebral toxicity, all describing leukoencephalopathy. We report the first case of oral MTX causing reversible cerebral diffusion-weighted imaging (DWI… (More)
DOI: 10.3174/ajnr.A2191

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