A case of livedoid vasculopathy associated with factor V Leiden mutation: successful treatment with oral warfarin.

Abstract

Livedoid vasculopathy is characterized by painful purpuric lesions on the extremities which frequently ulcerate and heal with atrophic scarring. It has been considered to be a vasculitic process but now there has been increasing evidence that abnormal coagulation plays a major role in the pathogenesis of this rare disorder. We report the case of a 19-year-old male who had been suffering from recurrent painful ulcerations on both lower legs with atrophic scars for 4 years. A biopsy specimen revealed vasculopathy, and laboratory studies showed resistance to activated protein C with factor V Leiden mutation. Treatment with oral warfarin led to rapid improvement of the lesions.

DOI: 10.1080/09546630701670305

Cite this paper

@article{Kavala2008ACO, title={A case of livedoid vasculopathy associated with factor V Leiden mutation: successful treatment with oral warfarin.}, author={Mukaddes Kavala and Emek Kocaturk and Ilkin Zindanci and Zafer Turkoğlu and Sumeyye Altintas}, journal={The Journal of dermatological treatment}, year={2008}, volume={19 2}, pages={121-3} }