A case of keratoconus progression associated with the use of topical latanoprost

  title={A case of keratoconus progression associated with the use of topical latanoprost},
  author={Shiro Amano and Yoshiyuki Nakai and Akiko Ko and Kenji Inoue and Masato Wakakura},
  journal={Japanese Journal of Ophthalmology},
Latanoprost is a prostaglandin analog widely used to lower intraocular pressure (IOP) in patients with glaucoma. Its reported mechanism for lowering intraocular pressure includes upregulation of matrix metalloproteinases (MMPs) in uveoscleral fl ow. Topical latanoprost is therefore also likely to affect the metabolism and gene expression of MMPs and the extracellular matrix in the cornea. We report a patient with glaucoma and keratoconus. After the patient started taking latanoprost, the… 
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