A case of keratoconus progression associated with the use of topical latanoprost

@article{Amano2008ACO,
  title={A case of keratoconus progression associated with the use of topical latanoprost},
  author={Shiro Amano and Yoshiyuki Nakai and Akiko Ko and Kenji Inoue and Masato Wakakura},
  journal={Japanese Journal of Ophthalmology},
  year={2008},
  volume={52},
  pages={334-336}
}
Latanoprost is a prostaglandin analog widely used to lower intraocular pressure (IOP) in patients with glaucoma. Its reported mechanism for lowering intraocular pressure includes upregulation of matrix metalloproteinases (MMPs) in uveoscleral fl ow. Topical latanoprost is therefore also likely to affect the metabolism and gene expression of MMPs and the extracellular matrix in the cornea. We report a patient with glaucoma and keratoconus. After the patient started taking latanoprost, the… 
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Chapter 11 Cornea and Glaucoma
Glaucoma is an acquired optic neuropathy in which destruction of ganglion cells and fibers leads to irreversible visual field loss. The prevalence of glaucoma, a leading cause of visual impairment
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TLDR
Latanoprost has remarkable effects inhibiting cultured corneal stromal cells on 3H-thymidine,3h-leucine,3H-uridine,2H-proline uptakes and cellular migration, which indicates that latanop frost may induce the morphological and biochemical changes in cultured cornesal cells.
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TLDR
Interleukin-6, TNF-alpha, and MMP-9 are overexpressed in the tears of patients with keratoconus, indicating that the pathogenesis of keratconus may involve chronic inflammatory events.
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TLDR
Among the antiglaucoma drugs examined, only latanoprost stimulated collagen gel contraction mediated by human corneal fibroblasts in a concentration- and time-dependent manner, and none of the 3 drugs affected collagen degradation by cornean fibroblast or exhibited cytotoxicity at concentrations as high as 100 μM.
Latanoprost stimulates secretion of matrix metalloproteinases in tenon fibroblasts both in vitro and in vivo.
TLDR
Tenon fibroblasts contain the ability on the mRNA level to synthesize all enzymes of the MMP and TIMP family that are related to remodeling of the extracellular matrix, and the levels of MMP-3 and TimP-2 increase after treatment with latanoprost.
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TLDR
The hypothesis that increased MMP production by ciliary smooth muscle cells has a role in increasing uveoscleral outflow facility after topical PG administration is supported.