A case of hepatoma associated with hypoglycaemia and overproduction of IGF-II (E-21): beneficial effects of treatment with growth hormone and intrahepatic adriamycin.

@article{Hunter1994ACO,
  title={A case of hepatoma associated with hypoglycaemia and overproduction of IGF-II (E-21): beneficial effects of treatment with growth hormone and intrahepatic adriamycin.},
  author={Steven J Hunter and William H. Daughaday and Michael E. Callender and J Mcknight and E. M Mcilrath and J. D. Teale and A. Brew Atkinson},
  journal={Clinical endocrinology},
  year={1994},
  volume={41 3},
  pages={
          397-401; discussion 402
        }
}
We describe a case of recurrent hypoglycaemia associated with a hepatoma. During hypoglycaemia serum insulin was undetectable. Plasma insulin-like growth factor II (IGF-II) was not elevated although 71% of plasma IGF-II was present as big IGF-II (molecular weight 11 kDa) which probably represents a non-glycated form of pro-IGF-II. The GH response to hypoglycaemia was impaired and plasma levels of both IGF-I and the GH-dependent IGF binding protein (IGFBP-3) were low. A recently described… CONTINUE READING
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