A case of chromoblastomycosis with an unusual clinical manifestation caused by Phialophora verrucosa on an unexposed area: treatment with a combination of amphotericin B and 5‐flucytosine

  title={A case of chromoblastomycosis with an unusual clinical manifestation caused by Phialophora verrucosa on an unexposed area: treatment with a combination of amphotericin B and 5‐flucytosine},
  author={S-G Park and S.H. Oh and Suk Bae Suh and K.-H. Lee and Kee Yang Chung},
  journal={British Journal of Dermatology},
Chromoblastomycosis is a cutaneous and subcutaneous mycotic disease caused by the dematiaceous (black) fungi. Five species of fungi are known generally to be the cause: Fonsecaea pedrosoi, Phialophora verrucosa, Cladosporium carrionii, F. compacta and Rhinocladiella cerphilum. In infected tissue they can appear as pigmented sclerotic bodies, commonly called ‘copper pennies’, which are pathognomonic of chromoblastomycosis. The infection usually occurs through traumatic skin inoculation, with the… 
Extensive chromoblastomycosis caused by Fonsecaea pedrosoi successfully treated with a combination of amphotericin B and itraconazole.
A case of extensive chromoblastomycosis of 22 years duration caused by F. pedrosoi is reported and present treatments of the disease are unsatisfactory as one of the most common etiologic agents, Fonsecaea pedro soi is difficult to manage from a therapeutic point of view.
Chromoblastomycosis Caused by Fonsecaea pedrosoi
A 39-year-old male, who showed multiple, asymptomatic, scaly erythematous plaques on the left shin for 12 months, has chromoblastomycosis caused by Fonsecaea (F.) pedrosoi.
Chromoblastomycosis: clinical presentation and management
  • M. Ameen
  • Medicine
    Clinical and experimental dermatology
  • 2009
Chromoblastomycosis is an important subcutaneous mycotic infection that is endemic worldwide but more common in the tropics, and a variety of antifungal regimens often combined with various physical treatments can be used.
Continuing medical education
The article provides an update of epidemiological, clinical, diagnostic, and therapeutic features of Chromoblastomycosis, an occupational disease that predominates in tropical and subtropical regions, but there have several reports of cases in temperate regions.
A Clinico-Mycological Study on Suspected Cases of Chromoblastomycosis: Challenges in Diagnosis and Management.
A database comprising diagnostic clues and effective therapeutic intervention have been proposed for these rare subcutaneous mycoses from eastern India.
Molecular identification of Phialophora oxyspora as the cause of mycetoma in a horse.
An 18-year-old mare was evaluated for an oral mass that developed after extraction of a broken incisor that revealed multiple coalescing and ramifying foci of abscess formation, each containing a well-defined, discrete, black mass.
Successful treatment for chromoblastomycosis caused by Fonsecaea monophora: a report of three cases in Guangdong, China
Three cases of chromoblastomycosis caused by F.’monophora that were successfully treated with terbinafine and/or itraconazole are reported on.
Análise morfológica in vitro da ação de antifúngicos em cepas de Fonsecaea pedrosoi
ITZ proved to be the most effective drug in vitro against F. pedrosoi while 5-FC only provoked structures alterations in the highest concentration tested, suggesting a different morphological pattern after ITZ or TBF treatment during the in vitro susceptibility test.
Artículo original Casuística de cromomicosis en el estado Bolívar (1987-2010) y evaluación de la sensibilidad in vitro de dos aislados de Fonsecaea pedrosoi
Chromomycosis prevalence during the period studied was low (0.6 cases/year); nevertheless, this infection constitutes a health problem for risk populations, mainly agricultural and mining workers at Bolivar State who present verrucous lesions with a chronic evolution.


A case of chromoblastomycosis due to Phialophora verrucosa responding to treatment with fluconazole.
Surgical curettage of the exuberant, infected tissue with systemic fluconazole administration gave good therapeutic results with no relevant side effects, and histopathological diagnosis of chromo-blastomycosis was confirmed.
Chromoblastomycosis and phaeohyphomycosis: new concepts, diagnosis, and mycology.
  • M. Mcginnis
  • Medicine
    Journal of the American Academy of Dermatology
  • 1983
A case of chromoblastomycosis responding to treatment with itraconazole
A case which, in addition to characteristic clinical and histopathological features of chromoblastomycosis, displayed atypical, deep dermal/subcutataneous involvement, and showed a good response to itraconazole is reported.
Phialophora verrucosa infection in a BMT patient
This represents the first reported case of invasive P. verrucosa in a BMT patient leading to fatal hemorrhage, despite large cumulative doses of LAMB to which the organism remained susceptible.
Infections caused by black fungi.
The clinical nomenclature for infections caused by these microorganisms should be clear and concise so that, even with the recognition of new agents of disease and new methods of diagnosis and therapy, the terms still apply.
Treatment of chromoblastomycosis.
Phialophora gougerotii: an opportunistic fungus in a patient treated with steroids.
This case is presented as a report of P. gougerotii causing infection secondary to 5 years continuous steroid therapy for rheumatoid arthritis.
The results support those of previous trials, suggesting that itraconazole is an effective compound against chromoblastomycosis due to Fonsecaea pedrosoi.
Successful treatment of chromoblastomycosis with itraconazole
  • R. Yu
  • Medicine, Biology
  • 1995
An unusual severe case of chromoblastomycosis due to Cladosporium carrionii unresponsive to 5‐FC and some azoles is reported and the patient had a complete clinical and mycological recovery without any side‐effects.
Dematiaceous fungi
  • S. Revankar
  • Medicine, Biology
    Seminars in respiratory and critical care medicine
  • 2004
Dematiaceous fungi are responsible for a wide variety of infectious syndromes and may have unique pathogenic mechanisms owing to the presence of melanin in their cell walls, which imparts the characteristic dark colour to their spores and hyphae.