[A case of advanced rectal cancer responding to oral UFT and Leucovorin-based preoperative chemoradiation therapy].

Abstract

We report a case of a 44-year-old male with advanced lower rectal cancer that showed a significant effect after preoperative chemoradiation therapy. Preoperative radiation and chemotherapy included whole pelvis irradiation (30 Gy in total), oral UFT (500 mg/day), and Leucovorin (75 mg/day) was administered daily for 4 weeks. Consequently, the patient underwent a total pelvic exenteration with lymph node dissection (D 3). Histopathological findings showed: invasion to peritoneum(Ai); stage IIIa with n(-); and histological grading, Grade 2. Preoperative chemoradiation therapy appears to be effective for locally advanced lower rectal cancer.

Cite this paper

@article{Shibahara2006ACO, title={[A case of advanced rectal cancer responding to oral UFT and Leucovorin-based preoperative chemoradiation therapy].}, author={Kotaro Shibahara and Takahiro Hirazuka and Manabu Yamamoto and Mizuki Ninomiya and Kojiro Mashino and Kyuzo Fuji and Tetsuo Ikeda and Tadashi Kahno}, journal={Gan to kagaku ryoho. Cancer & chemotherapy}, year={2006}, volume={33 10}, pages={1481-3} }