A case of γ1-heavy chain deposition disease successfully treated with melphalan and prednisolone therapy.

@article{Oe2010ACO,
  title={A case of γ1-heavy chain deposition disease successfully treated with melphalan and prednisolone therapy.},
  author={Yuji Oe and Izaya Nakaya and Mayumi Yahata and Tsutomu Sakuma and Hiroshi Sato and Jun Soma},
  journal={Internal medicine},
  year={2010},
  volume={49 14},
  pages={1411-5}
}
Heavy chain deposition disease (HCDD) is characterized by glomerular and tubular deposition of non-amyloidotic monoclonal heavy chains without associated light chains. We describe a case of gamma1-HCDD who presented with nephrotic syndrome, microhematuria, and hypocomplementemia. Renal biopsy showed lobular and nodular glomerulosclerosis along with IgG and C3 deposition. Electron microscopy revealed electron-dense deposits on the glomerular and tubular basement membranes and mesangium. Congo… CONTINUE READING
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