A case for a non-transgenic animal model of Alzheimer's disease.

  title={A case for a non-transgenic animal model of Alzheimer's disease.},
  author={Andreas Stephan and Anthony G Phillips},
  journal={Genes, brain, and behavior},
  volume={4 3},
Alzheimer's disease (AD) is associated with an early impairment in memory and is the major cause of dementia in the elderly. beta-Amyloid (Abeta) is believed to be a primary factor in the pathogenic pathway leading to dementia. Mounting evidence suggests that this syndrome begins with subtle alterations in synaptic efficacy prior to extensive neuronal degeneration and that the synaptic dysfunction could be caused by diffusible oligomeric assemblies of Abeta. This paper reviews the findings from… CONTINUE READING

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