A case-control study of the HER2 Ile655Val polymorphism in relation to risk of invasive breast cancer

@article{Nelson2004ACS,
  title={A case-control study of the HER2 Ile655Val polymorphism in relation to risk of invasive breast cancer},
  author={Stephanie E Nelson and Michael N. Gould and John M. Hampton and Amy Trentham-Dietz},
  journal={Breast Cancer Research},
  year={2004},
  volume={7},
  pages={R357 - R364}
}
Overexpression of the HER2 proto-oncogene in human cancer cells has been associated with a poor prognosis, and survival improves with therapy targeting the HER2 gene. Animal studies and protein modeling suggest that the Ile655Val polymorphism located in the transmembrane domain of the HER2 protein might influence breast cancer development by altering the efficiency of homodimerization. To investigate this genetic polymorphism, incident cases of invasive breast cancer (N = 1,094) and population… CONTINUE READING
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