A case-control study of cyclin D1 CCND1 870A-->G polymorphism and bladder cancer.

@article{Cortessis2003ACS,
  title={A case-control study of cyclin D1 CCND1 870A-->G polymorphism and bladder cancer.},
  author={Victoria K. Cortessis and Kimberly D. Siegmund and Shanyan Xue and Ronald K. Ross and Mimi C. Yu},
  journal={Carcinogenesis},
  year={2003},
  volume={24 10},
  pages={
          1645-50
        }
}
Expression of cyclin D1 is believed to lead to progression through the G1-S cell cycle checkpoint, and both experimental and pathological evidence suggest that over-expression of this protein may increase the risk of several cancers, including transition cell carcinoma of the bladder. Two major transcripts have been described for CCND1, the gene encoding cyclin D1. CCND1 870A-->G, a common single nucleotide polymorphism in the splice donor region of exon 4, may modulate expression of these… CONTINUE READING
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