A case-control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C. Japan HBV Genotype Research Group.

@article{Orito2001ACS,
  title={A case-control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C. Japan HBV Genotype Research Group.},
  author={Etsuro Orito and Masashi Mizokami and Hiroshi Sakugawa and Kojiro Michitaka and Kayo Ishikawa and Takafumi Ichida and Takeshi Okanoue and Hiroshi Yotsuyanagi and Shiro Iino},
  journal={Hepatology},
  year={2001},
  volume={33 1},
  pages={218-23}
}
Clinical and molecular virological differences were evaluated in 50 Japanese patients chronically infected with HBV of genotype B and C who were matched for age and sex as well as the severity of liver disease in a case-control study. Hepatitis B e antigen (HBeAg) was significantly less frequent (16% vs. 42%, P <.01), whereas antibody to HBeAg (anti-HBe) was significantly more common (84% vs. 56%, P <. 01) in genotype B than C patients. The predominance of mutants with G-to-A mutation at… CONTINUE READING

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