A case-control nutrigenomic study on the synergistic activity of folate and vitamin B12 in cervical cancer progression.

@article{Ragasudha2012ACN,
  title={A case-control nutrigenomic study on the synergistic activity of folate and vitamin B12 in cervical cancer progression.},
  author={Preethi N Ragasudha and Jissa Vinoda Thulaseedharan and Ramani Wesley and Puthuveetil Govindan Jayaprakash and Prema Lalitha and Madhavan Radhakrishna Pillai},
  journal={Nutrition and cancer},
  year={2012},
  volume={64 4},
  pages={
          550-8
        }
}
The present study was designed to identify the role of folate, B12, homocysteine, and polymorphisms of methylene tetrahydrofolatereductase (MTHFR) gene in cervical carcinogenesis among 322 women from Kerala, South India. Serum folate, vitamin B12 (chemiluminescence assay), and homocysteine (EIA) along with genetic polymorphisms of MTHFR gene (polymerase chain reaction/restriction fragment length polymorphism) were analyzed for 136 control subjects, 92 low-grade squamous intraepithelial lesions… CONTINUE READING
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