A case-control investigation of immune function gene polymorphisms and risk of testicular germ cell tumors.

@article{Purdue2007ACI,
  title={A case-control investigation of immune function gene polymorphisms and risk of testicular germ cell tumors.},
  author={Mark P Purdue and Lori C. Sakoda and BarryI. Graubard and Robert Welch and Stephen J. Chanock and Isabel A. Sesterhenn and Mark V. Rubertone and Ralph Loren Erickson and Katherine A McGlynn},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2007},
  volume={16 1},
  pages={
          77-83
        }
}
There is reason to suspect that testicular germ cell tumor (TGCT) development may be influenced by cytokines, secreted proteins that modulate tumor immune surveillance activity as well as a variety of processes in the testis. To address this hypothesis, we conducted a case-control analysis (508 cases, 608 controls) of 32 putatively functional single-nucleotide polymorphisms (SNP) in 16 immune function genes among non-Hispanic Caucasian participants in the U.S. Servicemen's Testicular Tumor… CONTINUE READING

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