A case-control family history study of autism.

@article{Bolton1994ACF,
  title={A case-control family history study of autism.},
  author={Patrick F. Bolton and H I Macdonald and Andrew Pickles and Patricia Delgado R{\'i}os and Susan P Goode and Mary Crowson and Anthony Bailey and Michael D. Rutter},
  journal={Journal of child psychology and psychiatry, and allied disciplines},
  year={1994},
  volume={35 5},
  pages={877-900}
}
Family history data on 99 autistic and 36 Down's syndrome probands are reported. They confirmed a raised familial loading for both autism and more broadly defined pervasive developmental disorders in siblings (2.9% and 2.9%, respectively, vs 0% in the Down's group) and also evidence for the familial aggregation of a lesser variant of autism, comprising more subtle communication/social impairments or stereotypic behaviours, but not mental retardation alone. Between 12.4 and 20.4% of the autism… CONTINUE READING
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