A cascade of protein aggregation bombards mitochondria for neurodegeneration and apoptosis under WWOX deficiency

@article{Sze2015ACO,
  title={A cascade of protein aggregation bombards mitochondria for neurodegeneration and apoptosis under WWOX deficiency},
  author={C I Sze and Y. M. Kuo and L J Hsu and Tao Fu and Michael F. Chiang and Jufang Chang and Nam Soo Chang},
  journal={Cell Death and Disease},
  year={2015},
  volume={6},
  pages={e1881-}
}
The presence of protein aggregates or inclusion bodies in the neurons or glial cells is one of the pathological hallmarks of neurodegenerative diseases, such as tauopathy in Alzheimer’s diseases (AD). Infectious agents or unknown etiological factors may cause de novo misfolding of peptides or proteins to form proteinaceous seeds or oligomers. These protein seeds lead to self-propagation of pathologic aggregates that impair neuronal functions at different brain regions for causing specific… CONTINUE READING
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