A cardiomyocyte-specific Wdr1 knockout demonstrates essential functional roles for actin disassembly during myocardial growth and maintenance in mice.

@article{Yuan2014ACW,
  title={A cardiomyocyte-specific Wdr1 knockout demonstrates essential functional roles for actin disassembly during myocardial growth and maintenance in mice.},
  author={Baiyin Yuan and P. N. Wan and Dandan Chu and Junwei Nie and Yunshan Cao and Wen Luo and Shuangshuang Lu and Jiong Chen and Zhongzhou Yang},
  journal={The American journal of pathology},
  year={2014},
  volume={184 7},
  pages={1967-80}
}
Actin dynamics are critical for muscle development and function, and mutations leading to deregulation of actin dynamics cause various forms of heritable muscle diseases. AIP1 is a major cofactor of the actin depolymerizing factor/cofilin in eukaryotes, promoting actin depolymerizing factor/cofilin-mediated actin disassembly. Its function in vertebrate muscle has been unknown. To investigate functional roles of AIP1 in myocardium, we generated conditional knockout (cKO) mice with cardiomyocyte… CONTINUE READING

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