A carcinogenicity study in mice of a beta-adrenergic antagonist, primidolol; increased total tumour incidence without tissue specificity.

@article{Faccini1981ACS,
  title={A carcinogenicity study in mice of a beta-adrenergic antagonist, primidolol; increased total tumour incidence without tissue specificity.},
  author={J. Faccini and E. Irisarri and A. Monro},
  journal={Toxicology},
  year={1981},
  volume={21 4},
  pages={
          279-90
        }
}
  • J. Faccini, E. Irisarri, A. Monro
  • Published 1981
  • Biology, Medicine
  • Toxicology
  • The beta-adrenergic blocking agent, primidolol hydrochloride, was administered, mixed in the diet, to mice (CD-1, Charles River, France) for 18 months. Experimental groups comprised untreated controls (100/sex) and those receiving 12.5, 25 and 50 mg drug/kg body weight (50/sex). There were no non-neoplastic lesions which could be attributed to the treatment. The pattern of tumour incidence was sex-related; in females the proportion of tumour-carrying animals was significantly higher in the top… CONTINUE READING
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    References

    SHOWING 1-10 OF 16 REFERENCES
    Tumorigenicity Assays of Sotalol Hydrochloride in Rats and Mice
    • 13
    The effect of propranolol on induction of rat liver tumors by a chemical carcinogen.
    • 15
    The value of the mouse in carcinogenicity testing.
    • 44
    Carcinogenicity of ‘Alderlin’ (Pronethalol) in Mice*
    • R. Howe
    • Chemistry, Medicine
    • Nature
    • 1965
    • 28
    Effect of single and twice daily doses of primidolol (UK-11,443) in hypertension.
    • 6
    Carcinogenesis and sanity.
    • F. Roe
    • Chemistry, Medicine
    • Food and cosmetics toxicology
    • 1968
    • 17