A carboxyl-terminal hydrophobic interface is critical to sodium channel function. Relevance to inherited disorders.

@article{Glaaser2006ACH,
  title={A carboxyl-terminal hydrophobic interface is critical to sodium channel function. Relevance to inherited disorders.},
  author={Ian W. Glaaser and John R. Bankston and Hua-jun Liu and Michihiro Tateyama and Robert S. Kass},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 33},
  pages={24015-23}
}
Perturbation of sodium channel inactivation, a finely tuned process that critically regulates the flow of sodium ions into excitable cells, is a common functional consequence of inherited mutations associated with epilepsy, skeletal muscle disease, autism, and cardiac arrhythmias. Understanding the structural basis of inactivation is key to understanding these disorders. Here we identify a novel role for a structural motif in the COOH terminus of the heart NaV1.5 sodium channel in determining… CONTINUE READING
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