A carboxy-terminal deletion mutant of protein kinase C beta II inhibits insulin-stimulated 2-deoxyglucose uptake in L6 rat skeletal muscle cells.

@article{Chalfant1996ACD,
  title={A carboxy-terminal deletion mutant of protein kinase C beta II inhibits insulin-stimulated 2-deoxyglucose uptake in L6 rat skeletal muscle cells.},
  author={Charles Edward Chalfant and Shigeo Ohno and Yusuke Konno and Alexander A. Fisher and Linda D. Bisnauth and James Watson and Denise R. Cooper},
  journal={Molecular endocrinology},
  year={1996},
  volume={10 10},
  pages={1273-81}
}
Alternative splicing of pre-mRNA encoding the carboxy-terminal (C-terminal) exons of protein kinase C beta (PKC beta) leads to the expression of two protein isoforms, PKC beta 1 and PKC beta II, with the potential for different functions. PKC beta II expression is regulated by insulin via alternative mRNA splicing. A physiological consequence of its activation was investigated in L6 rat skeletal muscle cells expressing GLUT4 transporters, a cell line in which PKC is involved in glucose… CONTINUE READING

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