A capacitative Ca2+ influx is required for sustained fluid secretion in sublingual mucous acini.

@article{Melvin1991ACC,
  title={A capacitative Ca2+ influx is required for sustained fluid secretion in sublingual mucous acini.},
  author={James E Melvin and L L Koek and Guo Hua Zhang},
  journal={The American journal of physiology},
  year={1991},
  volume={261 6 Pt 1},
  pages={G1043-50}
}
The Ca2+ dependence of muscarinic-induced fluid and electrolyte secretion was studied using rat sublingual mucous gland preparations. During stimulation, secretions from vascularly perfused glands were totally inhibited when perfused with a Ca(2+)-free medium. Fluid secretion correlated with sustained losses of 42K+ and 36Cl- content and sustained increases in 22Na+ content and the intracellular free Ca2+ concentration ([Ca2+]i) in fura-2-loaded acini. The magnitudes of the initial agonist… CONTINUE READING