A cap 'n' collar protein isoform contains a selective Hox repressor function.

@article{McGinnis1998AC,
  title={A cap 'n' collar protein isoform contains a selective Hox repressor function.},
  author={Nadine McGinnis and Erlend Ragnhildstveit and Alexey Veraksa and William J. McGinnis},
  journal={Development},
  year={1998},
  volume={125 22},
  pages={4553-64}
}
We have characterized a protein isoform (CncB) from the Drosophila cap 'n' collar locus that selectively represses cis-regulatory elements that are activated by the Hox protein Deformed. Of the three Cnc protein isoforms, CncB is expressed in a localized pattern in mandibular and labral cells of the head during mid-stages of embryogenesis. When CncB protein is absent or reduced, mandibular cells are homeotically transformed toward maxillary identities. This transformation is associated with… CONTINUE READING