A cannabinoid derived prototypical analgesic.

  title={A cannabinoid derived prototypical analgesic.},
  author={Lawrence S. Melvin and Martin R. Johnson and C A Harbert and George Milne and Albert Weissman},
  journal={Journal of medicinal chemistry},
  volume={27 1},
The synthesis and analgesic testing of 3-[4-(1,1-dimethylheptyl)-2-hydroxyphenyl]cyclohexanol (1) are described. Prior (SAR) studies led us to conclude that the pyran ring of 9-nor-9 beta-hydroxyhexahydrocannabinol (HHC) was not necessary for the expression of biological activity in this series of cannabinoids. Analysis of models and the use of molecular mechanics calculations suggested that a simpler compound, such as 1, would possess the biological activity of HHC. Compound 1 was prepared in… CONTINUE READING