A candidate tumor suppressor gene in human breast cancers.

@article{Schott1994ACT,
  title={A candidate tumor suppressor gene in human breast cancers.},
  author={D R Schott and Jenny C. Chang and Gang Deng and Wayne Kurisu and Wen Lin Kuo and Joe Gray and Helene S. Smith},
  journal={Cancer research},
  year={1994},
  volume={54 6},
  pages={1393-6}
}
We have isolated a candidate gene (designated Brush-1) located at 13q12-q13, proximal to the retinoblastoma gene (RB1). Brush-1 codes for a 4.7-kilobase mRNA expressed at high levels in normal breast epithelium but drastically reduced in 6 of 13 breast cancer cell lines. RB1 mRNA expression is at normal levels for 5 of these 6 lines suggesting a greater importance of Brush-1 for breast cancer. Four primary breast tumors which showed no loss of heterozygosity in the 13q13-q14 region demonstrated… CONTINUE READING

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References

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Loss of heterozygosity and p53 gene mutations in breast cancer

  • D. Deng, Chen, +7 authors H. S. Smith
  • Cancer Res.
  • 1994
Highly Influential
3 Excerpts

In vitro models in human breast cancer

  • H. S. Smith
  • Breast Diseases, Ed
  • 1991
1 Excerpt

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