A candidate tumor suppressor gene in human breast cancers.

  title={A candidate tumor suppressor gene in human breast cancers.},
  author={D R Schott and Jenny C. Chang and Gang Deng and Wayne Kurisu and Wen Lin Kuo and Joe Gray and Helene S. Smith},
  journal={Cancer research},
  volume={54 6},
We have isolated a candidate gene (designated Brush-1) located at 13q12-q13, proximal to the retinoblastoma gene (RB1). Brush-1 codes for a 4.7-kilobase mRNA expressed at high levels in normal breast epithelium but drastically reduced in 6 of 13 breast cancer cell lines. RB1 mRNA expression is at normal levels for 5 of these 6 lines suggesting a greater importance of Brush-1 for breast cancer. Four primary breast tumors which showed no loss of heterozygosity in the 13q13-q14 region demonstrated… CONTINUE READING


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