A candidate taste receptor gene near a sweet taste locus

@article{Montmayeur2001ACT,
  title={A candidate taste receptor gene near a sweet taste locus},
  author={J P Montmayeur and Stephen D. Liberles and Hiroaki Matsunami and Linda B. Buck},
  journal={Nature Neuroscience},
  year={2001},
  volume={4},
  pages={492-498}
}
The mechanisms underlying sweet taste in mammals have been elusive. Although numerous studies have implicated G proteins in sweet taste detection, the expected G protein-coupled receptors have not been found. Here we describe a candidate taste receptor gene, T1r3, that is located at or near the mouse Sac locus, a genetic locus that controls the detection of certain sweet tastants. T1R3 differs in amino acid sequence in mouse strains with different Sac phenotypes ('tasters' versus 'nontasters… 
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