A candidate taste receptor gene near a sweet taste locus

@article{Montmayeur2001ACT,
  title={A candidate taste receptor gene near a sweet taste locus},
  author={J P Montmayeur and Stephen D. Liberles and Hiroaki Matsunami and Linda B. Buck},
  journal={Nature Neuroscience},
  year={2001},
  volume={4},
  pages={492-498}
}
The mechanisms underlying sweet taste in mammals have been elusive. Although numerous studies have implicated G proteins in sweet taste detection, the expected G protein-coupled receptors have not been found. Here we describe a candidate taste receptor gene, T1r3, that is located at or near the mouse Sac locus, a genetic locus that controls the detection of certain sweet tastants. T1R3 differs in amino acid sequence in mouse strains with different Sac phenotypes ('tasters' versus 'nontasters… 
View on Springer
ncbi.nlm.nih.gov
411 Citations
Highly Influential Citations
20
Background Citations
137
Methods Citations
4
Results Citations
8

411 Citations

Citation Type

Citation Type

Sweet taste receptor gene variation and aspartame taste in primates and other species.
TLDR
The results identified a previously unknown site of aspartame interaction with the sweet receptor and suggest that the ability to taste aspartam might have developed during evolution to exploit a specialized food niche.
Genetics of sweet taste preferences.
Inbred mouse strains display marked differences in avidity for sweet solutions due in part to genetic differences among strains. Using several techniques, we have located a number of regions…
Mammalian Sweet Taste Receptors
Distinct Contributions of T1R2 and T1R3 Taste Receptor Subunits to the Detection of Sweet Stimuli
Evolution of the sweet taste receptor gene Tas1r2 in bats.
TLDR
The survey of available genome sequences revealed additional losses of Tas1r2 in horse, cat, chicken, zebra finch, and western clawed frog, indicating that sweet perception is not as conserved as previously thought, and no common dietary pattern among the Tas1 r2-lacking vertebrates was found, suggesting different causes for the losses.
A transient receptor potential channel expressed in taste receptor cells
TLDR
Heterologous expression studies of Trpm5 indicate that it functions as a cationic channel that is gated when internal calcium stores are depleted, and may be responsible for capacitative calcium entry in taste receptor cells that respond to bitter and/or sweet compounds.
Elucidation of mammalian bitter taste.
  • W. Meyerhof
  • Biology
    Reviews of physiology, biochemistry and pharmacology
  • 2005
TLDR
Transgenic expression of a human TAS2R in sweet or bitter taste receptor-expressing cells of mice induced either strong attraction or aversion to the receptor's cognate bitter tastant, suggesting dedicated taste receptor cells appear to function as broadly tuned detectors for bitter substances and are wired to elicit aversive behavior.
Allelic Variation of the Tas1r3 Taste Receptor Gene Selectively Affects Behavioral and Neural Taste Responses to Sweeteners in the F2 Hybrids between C57BL/6ByJ and 129P3/J Mice
TLDR
The range of ligand sensitivity of the T1R3 receptor is described using an in vivo approach and, to the authors' knowledge, is the first genetic mapping study of activity in gustatory nerves.
Taste information derived from T1R-expressing taste cells in mice.
TLDR
Mice are able to discriminate between sweet and umami tastes, and both tastes contribute to behavioural preferences for sweet or umami compounds, which implies that there may be a further population of T1R-expressing taste cells that mediate aversion to calcium taste.
An amino-acid taste receptor
TLDR
This work identifies and characterize a mammalian amino-acid taste receptor and shows that sequence differences in T1R receptors within and between species (human and mouse) can significantly influence the selectivity and specificity of taste responses.
...
...

References

SHOWING 1-10 OF 50 REFERENCES
A family of candidate taste receptors in human and mouse
TLDR
The identification of a family of candidate taste receptors (the TRBs) that are members of the G-protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells are reported.
A Novel Family of Mammalian Taste Receptors
T2Rs Function as Bitter Taste Receptors
A Plethora of Taste Receptors
Molecular identification of a taste receptor gene for trehalose in Drosophila.
TLDR
Results provide direct evidence that Tre1 encodes a putative taste receptor for trehalose in Drosophila, and overexpression of the Tre1 gene restored the taste sensitivity to tre Halose in theTre1 deletion mutant.
Putative Mammalian Taste Receptors A Class of Taste-Specific GPCRs with Distinct Topographic Selectivity
A metabotropic glutamate receptor variant functions as a taste receptor
TLDR
A GPCR cloned from rat taste buds and functionally expressed in CHO cells is described, which shows an unusual concentration–response relationship and the similarity of its properties to MSG taste suggests that this receptor is a taste receptor for glutamate.
High-resolution genetic mapping of the saccharin preference locus (Sac) and the putative sweet taste receptor (T1R1) gene (Gpr70) to mouse distal Chromosome 4
TLDR
A high-resolution analysis of the chromosomal localization of the Gpr70 and Sac loci in the F2 hybrids and 129.B6-Sac partially congenic mice originating from these two strains demonstrates that they are different loci.
Transduction of bitter and sweet taste by gustducin
TLDR
Gustducin is a principal mediator of both bitter and sweet signal transduction, and its role in taste transduction is investigated by generating and characterizing mice deficient in the gustducin α-subunit.
Multiple human taste receptor sites: a molecular modeling approach.
TLDR
An optimal subset of seven fragment types out of the 12, which significantly and best accounted for the 91 pairwise taste distances between all 14 modeled tastants are presented as good candidates to be recognized by the same number of distinct taste receptors.
...
...