A candidate gene study reveals association between a variant of the Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) gene and systemic sclerosis

@inproceedings{Marangoni2015ACG,
  title={A candidate gene study reveals association between a variant of the Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) gene and systemic sclerosis},
  author={Roberta Gonçalves Marangoni and Benjamin Korman and Yannick Allanore and Philippe Dieud{\'e} and Loren L. Armstrong and Margarita Rzhetskaya and Monique Hinchcliff and Mary Carns and Sofia Podlusky and Sanjiv J. Shah and B{\'a}rbara Ruiz and {\'E}ric Hachulla and Kiet Phong Tiev and J L Cracowski and John A Varga and M. Geoffrey Hayes},
  booktitle={Arthritis research & therapy},
  year={2015}
}
INTRODUCTION The multifunctional nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ) has potent anti-fibrotic effects, and its expression and activity are impaired in patients with systemic sclerosis (SSc). We investigated PPAR-γ gene (PPARG) single nucleotide polymorphisms (SNPs) associated with SSc. METHODS Tag SNPs spanning PPARG were genotyped in a European ancestry US discovery cohort comprising 152 SSc patients and 450 controls, with replication of our top signal… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS
4 Citations
53 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 53 references

looking into the postgenomic era

  • Mayes MD. The genetics of scleroderma
  • Curr Opin Rheumatol. 2012;24:677–84. Marangoni…
  • 2015
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…