A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE

@inproceedings{Sandling2011ACG,
  title={A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE},
  author={Johanna K. Sandling and Sophie Garnier and Snaevar Sigurdsson and Chuan Wang and Gunnel Nordmark and Iva Gunnarsson and Elisabet Svenungsson and Leonid Padyukov and Gunnar K Sturfelt and Andreas J{\"o}nsen and Anders A. Bengtsson and Lennart Truedsson and Catharina Eriksson and Solbritt Rantap{\"a}{\"a}-Dahlqvist and Anders M{\"a}larstig and Rona J. Strawbridge and Anders Hamsten and Lindsey A. Criswell and Robert R. Graham and Timothy W. Behrens and M L Eloranta and Gunnar Alm and Lars R{\"o}nnblom and Ann-Christine Syv{\"a}nen},
  booktitle={European Journal of Human Genetics},
  year={2011}
}
Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease in which the type I interferon pathway has a crucial role. We have previously shown that three genes in this pathway, IRF5, TYK2 and STAT4, are strongly associated with risk for SLE. Here, we investigated 78 genes involved in the type I interferon pathway to identify additional SLE susceptibility loci. First, we genotyped 896 single-nucleotide polymorphisms in these 78 genes and 14 other candidate genes in 482 Swedish SLE… CONTINUE READING

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