A candidate gene association study on preterm delivery: application of high-throughput genotyping technology and advanced statistical methods.

@article{Hao2004ACG,
  title={A candidate gene association study on preterm delivery: application of high-throughput genotyping technology and advanced statistical methods.},
  author={Ke Hao and Xiaobin Wang and Tianhua Niu and Xin Xu and Ang Li and Weili Chang and Lin Wang and Guang Yu Li and Nan Laird and Xiping Xu},
  journal={Human molecular genetics},
  year={2004},
  volume={13 7},
  pages={683-91}
}
Preterm delivery (PTD) is the leading cause of infant mortality and morbidity worldwide. The etiology of PTD is largely unknown but is believed to be complex, encompassing multiple genetic and environmental determinants. To date, reports of genetic studies on PTD are sparse. We conducted a large-scale case-control study exploring the associations of 426 single-nucleotide polymorphisms with PTD in 300 mothers with PTD and 458 mothers with term deliveries at the Boston Medical Center. Twenty-five… CONTINUE READING