A cancer modifier role for parathyroid hormone-related protein

  title={A cancer modifier role for parathyroid hormone-related protein},
  author={Giacomo Manenti and Bernard Peissel and Manuela Gariboldi and Felicia Stefania Falvella and Daniela Zaffaroni and Biagino Allaria and Simonetta Pazzaglia and Simonetta Rebessi and Vincenzo Covelli and Anna Saran and Tommaso A Dragani},
The parathyroid hormone-related protein (PTHrP) gene (Pthlh) maps in the distal region of mouse chromosome 6 that contains a quantitative trait locus associated with genetic predisposition to skin tumorigenesis. Here, we report a genetic polymorphism located in the osteostatin encoding region of the Pthlh gene and that produces Thr/Pro PTHrP variants. PthlhThr and PthlhPro alleles were significantly linked with resistance and susceptibility to skin carcinogenesis in phenotypically selected Car… CONTINUE READING
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