A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme

  title={A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme},
  author={Mireille Dumoulin and Alexander M. Last and Aline Desmyter and Klaas Decanniere and Denis Canet and G{\"o}ran Larsson and Andrew Spencer and David B. Archer and Jurgen Sasse and Serge Muyldermans and Lode Wyns and Christina Redfield and Andr{\'e} Matagne and Carol V Robinson and Christopher M. Dobson},
Amyloid diseases are characterized by an aberrant assembly of a specific protein or protein fragment into fibrils and plaques that are deposited in various organs and tissues, often with serious pathological consequences. Non-neuropathic systemic amyloidosis is associated with single point mutations in the gene coding for human lysozyme. Here we report that a single-domain fragment of a camelid antibody raised against wild-type human lysozyme inhibits the in vitro aggregation of its… CONTINUE READING
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