A camel passes through the eye of a needle: protein unfolding activity of Clp ATPases.

@article{Zolkiewski2006ACP,
  title={A camel passes through the eye of a needle: protein unfolding activity of Clp ATPases.},
  author={Michal Zolkiewski},
  journal={Molecular microbiology},
  year={2006},
  volume={61 5},
  pages={1094-100}
}
Clp ATPases are protein machines involved in protein degradation and disaggregation. The common structural feature of Clp ATPases is the formation of ring-shaped oligomers. Recent work has shown that the function of all Clp ATPases is based on an energy-dependent threading of substrates through the narrow pore at the centre of the ring. This review gives an outline of known mechanistic principles of threading machines that unfold protein substrates either before their degradation (ClpA, ClpX… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 55 extracted citations

Similar Papers

Loading similar papers…