A call for replicating vector prime-protein boost strategies in HIV vaccine design.

@article{Malkevitch2004ACF,
  title={A call for replicating vector prime-protein boost strategies in HIV vaccine design.},
  author={Nina V Malkevitch and Marjorie Robert-Guroff},
  journal={Expert review of vaccines},
  year={2004},
  volume={3 4 Suppl},
  pages={S105-17}
}
A key challenge to HIV vaccine development is the integration of HIV proviral DNA into the host genome upon infection. Therefore, an optimal vaccine should block infection within hours of viral exposure, providing 'sterilizing immunity' at mucosal sites and in blood via potent, broadly reactive antibody to the HIV envelope glycoprotein. This is difficult due to the envelope's conformational complexity and sequence diversity. Antibodies that do not completely prevent infection nevertheless could… CONTINUE READING

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