A calcium-permeable stretch-activated cation channel in renal proximal tubule.

  title={A calcium-permeable stretch-activated cation channel in renal proximal tubule.},
  author={Dragana Filipovi{\'c} and Henry Sackin},
  journal={The American journal of physiology},
  volume={260 1 Pt 2},
Isolated Necturus proximal tubules were split to expose the apical membrane surface for patch clamping. When both pipette and bath solutions contained only Ca, N-methyl-D-glucamine, and methanesulfonate, inwardly directed Ca currents were observed through a stretch-activated (SA) cation channel with conductance of 18 +/- 1 pS (n = 19). The SA cation channel exhibited little discrimination among Na, K, and Ca but was at least nine times more selective for cations than anions. The channel was not… CONTINUE READING


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